Vaccine composition comprising at least two valences, one enhanced with adjuvant and not the other

Abstract

The invention concerns a vaccine composition comprising two valences; (i) a first valence which is adjuvant-enhanced with aluminium hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more —O— acetyl groups and which is not adsorbed with aluminium oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents said adsorptiuon. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) the Hepatite A valence, adsorbed on aluminium hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of the Salmonella typhi capsule.

Dependencies are inferred from the claim text.