Loading patent…
AssigneesCommissariat a l'Energie Atomique, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsBernard Mailere, Isabelle Bourgault-Villada, Sandra Pouvelle-Moratille, Jean-Gerard Guillet
Estimating the term…
The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.
A mixture of peptides derived from an E6 protein and/or from an E7 protein of an HPV involved in cervical cancer or benign lesions of the skin, characterized in that each of the peptides included in said mixture binds to at least one HLA-DRB1 (1st gene) molecule the frequency of which is greater than 5% in the Caucasian population and, optionally, to at least one HLA-DRB3, HLA-DRB4 or HLA-DRB5 (2nd gene) molecule, with a binding activity <1 000 nM, preferably <800 nM, said mixture of peptides binding to at least eight HLA class II molecules, the frequency of which is greater than 5% in the Caucasian population, encoded by the alleles selected from the group consisting of the alleles HLA DRB1*0101, DRB1*0301, DRB1*0401, DRB1*0701, DRB1*1101, DRB1*1301 and DRB1*1501 (DR1, DR3, DR4, DR7, DR11, DR13 and DR15 molecules) (1st gene) and the alleles DRB3*0101, DRB4*0101 and DRB5*0101 (B3, B4 and B5) (2nd gene).
Dependencies are inferred from the claim text.