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US 2004/0170631 A1Published application
Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
OwnerOron Yacoby-Zeevi, Tuvia Peretz +8inventors
InventorsOron Yacoby-Zeevi, Tuvia Peretz, Daphna Miron, Yinon Shlomi, Iris Pecker, Maty Ayal-Hershkovitz, Elena Feinstein, Joel M. Van Gelder, Israel Vlodavsky, Yael Friedmann
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Abstract
Specific anti-heparanase antibodies which bind specifically to heparanase having sequence homology to human heparanase, which can be used to treat and diagnose conditions associated with heparanase catalytic activity, for purification of heparanase, and for drug development in heparanase associated conditions are disclosed.
Claims29
A method of targeted drug delivery to a tissue of a patient, the tissue expressing heparanase, the method comprising:
- providing a complex of a drug directly or indirectly linked to an anti-heparanase antibody;
- and administering said complex to the patient.
Dependencies are inferred from the claim text.