Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms
AssigneeMorehouse School of Medicine
InventorsJames W. Lillard JR., Pier Nicole Hannah, Shailesh Singh, Jonathan K. Stiles
Life of this patent
Estimating the term…
Abstract
The present invention provides a means of inhibiting the growth and metastasis of cancer cells by administering anti-chemokine antibodies. It is possible to identify the particular chemokines which are over-expressed in the tumor using methods of the invention and administer antibodies against that over-expressed chemokine.
Claims14
A method of treating a host having a condition arising from malignancy comprising of administration of a composition containing at least one antibody or antigen-binding fragment which binds a chemokine which is known to be over-expressed in the particular malignancy present in said host to said host in a pharmaceutically acceptable carrier.
A method of treating a host having a malignancy comprising the steps of:
- 1) identifying the level of expression of several differing chemokines in the malignant tissue,
- 2) evaluating the extent to which any particular chemokines are over-expressed, and
- 3) administering a malignancy inhibiting effective amount of a composition containing at least one antibody or antigen-binding fragment that is known to bind to the over-expressed chemokine.
A method of inhibiting malignant cell migration and metastasis, by administration of a migration-inhibiting effective amount of at least one antibody or antigen-binding fragment which is chosen to bind to a chemokine known to be over-expressed in the particular type of malignant cell.
A method of identifying malignancy by exposing multiple samples of tissue or body fluids believed to contain malignant cells separately to different antibodies or antigen-binding fragments which are known to bind to particular chemokines.
Dependencies are inferred from the claim text.