Selected antibody compositions for binding to aminophospholipids
AssigneeBoard of Regents, The University of Texas System
InventorsPhilip E. Thorpe, Sophia Ran
Life of this patent
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Abstract
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread, and compositions and methods for utilizing these findings in the treatment of cancer and viral infections. Also disclosed are advantageous antibody, immunoconjugate and duramycin-based compositions and combinations that bind and inhibit anionic phospholipids and aminophospholipids, for use in the safe and effective treatment of cancer, viral infections and related diseases.
Claims92
A composition comprising a purified antibody, or antigen-binding fragment or immunoconjugate thereof, wherein said antibody binds to phosphatidylserine and effectively competes with the monoclonal antibody 3G4 (ATCC PTA 4545) for binding to phosphatidylserine.
A composition comprising a substantially cell impermeant duramycin derivative, comprising a duramycin peptide operatively attached to a cell impermeant group.
A composition comprising a duramycin peptide operatively attached to at least a first anti-viral agent.
A method for treating a viral infection, comprising administering to an animal in need thereof a biologically effective amount of composition comprising an antibody that binds to phosphatidylserine or phosphatidylethanolamine.
Dependencies are inferred from the claim text.