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OwnerBenjamin G. Davis, John Bryan Jones +3inventors
InventorsBenjamin G. Davis, John Bryan Jones, Richard R. Bott, Karl John Sanford, David Aaron Estell
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This invention provides chimeric molecules that are catalytic antagonists of a target molecule. The catalytic antagonists of this invention preferably comprise a targeting moiety attached to an enzyme that degrades the molecule specifically bound by the targeting moiety. The catalytic antagonists of this invention thus bind to a target recognized by the targeting moiety (e.g., a receptor) the enzyme component of the chimera then degrades all or part of the target. This typically results in a reduction or loss of activity of the target and release of the chimeric molecule. The chimeric molecule is then free to attack and degrade another target molecule.
A catalytic antagonist of a target molecule, said antagonist comprising a targeting moiety that specifically binds to said target molecule said targeting moiety being attached to an enzyme that degrades said target molecule to reduce binding of the target molecule to its cognate ligand and to said targeting moiety thereby resulting in the release of said antagonist thereby allowing said antagonist to bind and degrade another target molecule.
A method of degrading a target molecule, said method comprising contacting said target molecule with a catalytic antagonist comprising a targeting moiety that specifically binds to said target molecule said targeting moiety being attached to an enzyme that degrades said target molecule resulting in the release of said antagonist thereby allowing said antagonist to bind and degrade another target molecule.
An enzyme having altered substrate specificity said enzyme comprising a targeting moiety attached to a subsite comprising the substrate binding site of said enzyme.
A method of directing the activity of an enzyme to a specific target, said method comprising
A method of enhancing the activity of a drug that acts as an inhibitor of a receptor or an enzyme, said method comprising:
A method of inhibiting an enzyme or a receptor, said method comprising contacting the enzyme or receptor with a chimeric molecule comprising a ligand that binds said enzyme or receptor attached to an enzyme that degrades the cognate ligand of said enzyme or receptor.
Dependencies are inferred from the claim text.