Methods and compositions using compounds from fetal cells and tissues to improve condition of skin
OwnerChia Sooinventor
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Abstract
Compositions comprising one or more compounds expressed by fetal tissues for modulating skin conditions, methods of identifying the compounds, and methods of making and using the compounds are provided.
Claims53
A method of promoting skin regeneration comprising:
- a) identifying compounds expressed by fetal tissues that promote skin regeneration, and
- b) applying to skin of a mammal a composition comprising one or more compounds expressed by fetal tissues.
A method of promoting skin regeneration comprising:
- a) comparing compounds expressed by adult tissue and compounds expressed by fetal tissues,
- b) identifying compounds with higher expression in adult tissues,
- c) identifying compounds that block the expression of the compounds with higher expression in adult tissues and designating the compounds that block the expression of the compounds with higher expression in adult tissues as blocking compounds, and
- d) applying a composition comprising one or more of the blocking compounds to skin of a mammal,
- wherein the blocking compounds are selected from the group consisting of naturally derived compounds, recombinantly produced compounds, and combinations thereof.
A cosmetic, pharmaceutical, or dermatological skin care composition comprising compounds expressed by fetal tissues and a dermatologically or pharmaceutically acceptable carrier.
A cosmetic, pharmaceutical, or dermatological skin care composition comprising:
- a) from about 0.000000001% to about 10% by weight of individually purified compounds expressed by fetal tissues;
- b) about 1% to about 80% by weight of non-purified or partially purified compounds expressed by fetal tissues in enriched lysates, extracts, or media;
- b) from about 0.1% to about 10% by weight of hyaluronic acid;
- c) from about 0.000001% to about 10% by weight of at least one additional skin care active including lactose-1-phosphate, maltose-1-phosphate, mannose-6-phosphate, and lactose-6-phosphate;
- and
- d) a dermatologically or pharmaceutically acceptable carrier.
A method of promoting skin regeneration comprising applying to skin of a mammal a composition comprising an effective amount of a small leucine rich proteoglycan compound selected from the group consisting of fibromodulin (FM), lumican, decorin, biglycan, and combinations thereof, wherein the skin of a mammal is in the absence of a dermal wound.
A cosmetic, pharmaceutical, or dermatological skin care composition that promotes the regeneration of skin of a mammal, comprising an effective amount of a proteoglycan compound selected from the group consisting of FM, lumican, decorin, biglycan, and combinations thereof, wherein the skin of a mammal is in the absence of a dermal wound.
A method of modulating skin conditions comprising a step selected from the group consisting of:
- a) promoting collagen organization,
- b) modulating skin inflammatory conditions,
- c) modulating skin pigmentation, and
- d) combinations thereof.
Dependencies are inferred from the claim text.