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US 2004/0170611 A1Published application
Methods of modulating hair growth
AssigneeThe General Hospital Corporation, a Massachusetts corporation
InventorsBruce A. Morgan, Jiro Kishimoto, Robert Burgeson
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Abstract
The invention features methods of promoting hair growth in a subject. The methods include inducing or mimicking the effects of Wnt promoted signal transduction, e.g., by increasing the level of Wnt protein or administering an agent which mimics an effect of Wnt promoted signal transduction, e.g., by administering lithium chloride. Methods of inhibiting hair growth are also provided.
Claims24
A method of promoting hair growth in a subject, comprising:
- providing a dermal papilla (DP) cell;
- culturing the DP cell in the presence of a Wnt polypeptide or a functional fragment or analog thereof, and
- grafting the cultured DP cell onto the skin of a subject, thereby promoting hair growth in the subject.
Dependencies are inferred from the claim text.