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OwnerShimon Slavin, Olga Gurevitch +2inventors
InventorsShimon Slavin, Olga Gurevitch, Basan Gowda S. Kurkalli, Tatyana Prigeshina
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A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and/or a cranio-facial-maxillary bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.
Use of a mixture comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) as a graft of mesenchymal progenitor cells for transplantation into a joint and/or a cranio-facial-maxillary bone of a subject in need.
The use according to any one of the preceding claims, wherein said transplantation is for the treatment of a patient suffering from any one of hereditary or acquired bone disorder, hereditary or acquired cartilage disorder, a malignant bone or cartilage disorder, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease.
The use according to any one of the preceding claims, further optionally comprising a pharmaceutically acceptable carrier or diluent.
Use of a mixture comprising BMC and DBM and/or MBM, in the preparation of a composition for the treatment of a damaged joint or degenerative arthropathy, and/or for the treatment of a patient suffering from any one of hereditary or acquired bone disorder, hereditary or acquired cartilage disorder, a malignant bone or cartilage disorder, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease.
Use of a mixture comprising BMC and DBM and/or MBM, in the preparation of a composition to be used for transplantation, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure.
A method of treating a damaged joint or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone in a mammal in need of such treatment, comprising administering into an affected joint or bone of said mammal a mixture comprising BMC with DBM and/or MBM, said mixture optionally further comprising a pharmaceutically acceptable carrier or diluent and/or additional active agents.
The method according to any one of the preceding claims, wherein the ratio between the transplanted BMC and DBM is between 1:1 and 20:1 (volume:volume).
A non-invasive implantation method for support of implants of joints or other musculoskeletal implants, comprising introducing a graft into a joint or a cranio-facial-maxillary bone of a subject in need, wherein said graft comprises a mixture of BMC and DBM and/or MBM.
Dependencies are inferred from the claim text.