Use of a lentiviral vector in the treatment of pain
OwnerRob Barber, Mimoun Azzouz +2inventors
InventorsRob Barber, Mimoun Azzouz, Nicholas D. Mazarakis, Susan Kingsman
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Abstract
Provided is a method for treating and/or preventing pain, in which a vector system is administered such that an EOI is delivered to a DRG of the subject. Also provided is a method for delivering an EOI to the spinal cord using such a vector system. Further provided is a method for identifying and/or validating an EOI by delivering a test EOI to target cell; analyzing the effect of the EOI on the target cell; and selecting an EOI with therapeutic potential. An EOI identified or validated by such a method, useful in the prevention and/or treatment of pain, is thereby provided as well.
Claims24
A method for treating or preventing pain in a subject, comprising administering a lentiviral vector system comprising an entity of interest (EOI) to a dorsal root ganglion cell (DRG) in the subject.
A method for identification or validation of an EOI useful in the prevention or treatment of pain comprising
- (i) delivering a test EOI to target cell;
- (ii) analyzing the effect of the EOI on the target cell;
- and
- (iii) selecting an EOI with therapeutic potential.
Dependencies are inferred from the claim text.