Dominant negative proteins and methods thereof
OwnerJohn R. Desjarlais, Malu Lourdes G. Tansey +1inventors
InventorsJohn R. Desjarlais, Malu Lourdes G. Tansey, Bassil I. Dahiyat
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Abstract
The invention relates to novel proteins with TNFSF antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNFSF-related disorders.
Claims44
A method of antagonizing a naturally occurring TNFSF protein comprising contacting a naturally occurring TNFSF monomer protein with a variant TNFSF monomer protein comprising at least a variant extracellular domain of a TNFSF protein, to form a mixed TNFSF oligomer.
A method of making a mixed TNFSF oligomer comprising contacting at least one variant TNFSF protein comprising at least a variant extracellular domain of a TNFSF monomer protein with a homo-oligomer comprising naturally occurring TNFSF monomer proteins, under conditions whereby at least one naturally occurring TNFSF monomer exchanges with a variant monomer to form a mixed oligomer.
A mixed TNFSF oligomer comprising at least one variant TNFSF protein comprising at least a variant extracellular domain of a TNFSF monomer protein and a naturally occurring TNFSF monomer protein.
A variant TNFSF monomer protein comprising at least a variant extracellular domain of a TNFSF protein.
A variant TNFSF protein wherein said variant TNFSF protein will interact with a receptor interface in at least one receptor binding site to render said receptor substantially incapable of activating receptor signaling.
Dependencies are inferred from the claim text.