Polysubstituted polycarboxylic phosphoamide biopolymers, methods for their production and uses of compositions derived therefrom
OwnerEmilio Barraganinventor
Life of this patent
Estimating the term…
Abstract
The present invention provides polysubstituted polycarboxylic phosphoamide biopolymers (PPPBs) comprising polysaccharides and glycopolypeptides attached to a phospho-citrate backbone. Phosphorylation of the biopolymers yields phosphorylated polysubstituted polycarboxylic phosphoamide biopolymers (pPPPBs) which can be used as inflammatory response modulators, immunomodulators and/or biological response modifiers. Methods for producing the PPPBs in yeast subjected to multiple chemical stressors, and uses of compositions derived therefrom, are provided.
Claims42
A biopolymer that is a polycarboxylic phosphoamide polysubstituted with glycopolypeptides and/or polysaccharides, wherein said biopolymer is obtained from yeast cells which have been treated with one or more stressors.
A biopolymer as in Formula 1,
- 6
- wherein R1, R2, R3 and R4 are selected from the group comprising a hydrogen, a glycopolypeptide, a polysaccharide, a branched glycopolypeptide, and a branched polysaccharide, wherein said biopolymer comprises up to four glycopolypeptides in total, four polysaccharides in total, or any combination of glycopolypeptides and/or polysaccharides totaling four, and wherein the biopolymer must contain at least one glycopolypeptide or at least one polysaccharide moiety.
A biopolymer derived from yeast cells comprising polycarboxylic phosphoamide polysubstituted with glycopolypeptides and polysaccharides having the formula:
- [(C6H5O10NP)-(glycopolypeptide)X-(polysaccharide)Y]
- wherein, x equals 0-4;
- y equals 0-4, and wherein the sum of x plus y is less than or equal to 4 and greater than or equal to 1.
A phosphorylated derivative of a biopolymer derived from yeast cells comprising polycarboxylic phosphoamide polysubstituted with glycopolypeptides and polysaccharides having the formula:
- [(C6H5O10NP)-(glycopolypeptide)X-(polysaccharide)Y]-[(PO4)z]
- wherein, z indicates a ratio of phosphate groups to biopolymer such that the weight of phosphate groups constitutes less than or equal to 3% of the total weight of the final phosphorylated biopolymer;
- x equals 0-4;
- y equals 0-4, and wherein the sum of x plus y is less than or equal to 4 and greater than or equal to 1.
Dependencies are inferred from the claim text.