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AssigneeUniversity of Pittsburgh
InventorsEric J. Beckman, Michael Buckley, Sudha Agarwal, Jianying Zhang
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An adhesive including a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group. Preferably, the functional groups are hydroxyl groups. The multi-functional precursor compounds are biocompatible. Multi-aminc functional precursors of the multi-isocyanate functional molecules are also biocompatible. As discussed, above, the mixture of molecules preferably has an average isocyanate functionality of at least 2.1 and, more preferably, has an average isocyanate functionality of at least 2.5. As also described above, the mixture of molecules preferably has a viscosity in the range of approximately 1 to approximately 100 centipoise. The mixture of molecules forms a crosslinked polymer network upon contact with the organic tissue in the presence of water. The crosslinked polymer network is biocompatible and biodegradable. The crosslinked polymer network degrades into degradation products including the precursor molecules and the multi-amine functional precursors.
A method of applying an adhesive to organic tissue, comprising the step of applying a mixture of molecules to the organic tissue, the molecules having terminal isocyanate functional groups, the mixture of molecules having an average isocyanate functionality of at least 2.1, the mixture of molecules having a viscosity in the range of approximately 1 to approximately 100 centipoise, the mixture of molecules forming a crosslinked polymer network upon contact with the organic tissue in the presence of water, the crosslinked polymer network being biocompatible and biodegradable, the crosslinked polymer network biodegrading into molecules that are biocompatible.
An adhesive, comprising a mixture of isocyanate capped molecules formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group, the multi-functional precursor compounds being biocompatible, multi-amine functional precursors of the multi-isocyanate functional molecules also being biocompatible, the mixture of molecules having an average isocyanate functionality of at least 2.1, the mixture of molecules having a viscosity in the range of approximately 1 to approximately 100 centipoise, the mixture of molecules forming a crosslinked polymer network upon contact with the organic tissue in the presence of water, the crosslinked polymer network being biocompatible and biodegradable, the crosslinked polymer network degrading into degradation products including the precursor molecules and the multi-amine functional precursors.
An adhesive, comprising a mixture of isocyanate capped prepolymers formed by reacting multi-isocyanate functional molecules with multi-functional precursor molecules including terminal functional groups selected from the group consisting of a hydroxyl group, a primary amino group and a secondary amino group, the multi-functional precursor compounds being biocompatible, multi-amine functional precursors of the multi-isocyanate functional molecules also being biocompatible, at least one of the multi-functional precursors being a flexible biocompatible polymer having a number average molecular weigh of at least 50, the mixture of prepolymers having an average isocyanate functionality of at least 2.1, the mixture of prepolymer being spreadable, the mixture of prepolymers forming a crosslinked polymer network upon contact with the organic tissue in the presence of water, the crosslinked polymer network being biocompatible and biodegradable, the crosslinked polymer network degrading into degradation products including the precursor molecules and the multi-amine functional precursors.
Dependencies are inferred from the claim text.