Delivery of rizatriptan or zolmitriptan through an inhalation route

A composition for delivery of zolmitriptan consisting of a condensation aerosol

• a) formed by volatilizing a thin layer of zolmitriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of zolmitriptan and condensing the heated vapor of zolmitriptan to form condensation aerosol particles,
• b) wherein said condensation aerosol particles are characterized by less than 5% zolmitriptan degradation products, and
• c) the condensation aerosol has an MMAD of less than 3 microns.

A method of producing rizatriptan in an aerosol form comprising:

• a. heating a thin layer of rizatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the rizatriptan to form a heated vapor of the rizatriptan, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the rizatriptan comprising less than 5% rizatriptan degradation products, and an aerosol having an MMAD of less than 3 microns.

A method of producing zolmatriptan in an aerosol form comprising:

• a. heating a thin layer of zolmatriptan on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the zolmatriptan to form a heated vapor of the zolmatriptan, and
• b. during said heating, passing air through the heated vapor to produce aerosol particles of the zolmatriptan comprising less than 5% zolmatriptan degradation products, and an aerosol having an MMAD of less than 3 microns.