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US 2004/0170563 A1Published application
Magnetic resonance imaging agents for the delivery of therapeutic agents
OwnerThomas J. Meadeinventor
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Abstract
The invention relates to novel magnetic resonance imaging contrast agents that report on physiological events in a conditional fashion and simultaneously detect the delivery and/or activation of a therapeutically active agent.
Claims17
A method comprising:
- a) administering an activatible MRI agent comprising a chelator and a paramagnetic metal ion that is coordinatively saturated by said chelator and a therapeutic blocking moiety covalently attached to said chelator, wherein said therapeutic blocking moiety comprises a cleavage site and an agent therapeutically active in cancer;
- b) cleaving said cleavage site such that:
- i) said agent therapeutically active in cancer interacts with a target substance;
- and,
- ii) the T1 of said MRI agent is decreased;
- and,
- c) producing a magnetic resonance image of a cell, tissue, or patient and eliciting a therapeutic effect.
4 more elements
Dependencies are inferred from the claim text.