Process for removing metals from liquids
AssigneeBristol-Myers Squibb Company
InventorWansheng Liu
Life of this patent
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Abstract
A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) 1 wherein R1, R2, R3, R4, HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.
Claims29
A method of removing a metal from a metal-containing liquid mixture, comprising contacting said liquid mixture with a solid extractant having a metal-binding functionality, said metal-binding functionality comprising an unsubstituted or substituted phosphine group, said metal-binding functionality being connected to said solid extractant directly or via a linking moiety which does not include at least one of a hydrocarbylsilyl residue or a polyamine residue.
A method of recovering a drug substance from a liquid medium containing said drug substance together with at least one metal, said method comprising
- contacting the liquid medium with a solid extractant having a metal-binding functionality, said metal-binding functionality comprising an unsubstituted or substituted phosphine group, said metal-binding functionality being connected to said solid extractant directly or via a linking moiety which does not include at least one of a hydrocarbylsilyl residue or a polyamine residue;
- and
- separating said drug substance from said liquid medium.
A method of recovering a drug substance comprising 2′-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1′]-biphenyl-3-yloxyacetic acid, or a salt, solvate, stereoisomer, precursor, prodrug ester, or intermediate thereof, from a liquid medium containing said drug substance together with at least one metal, said method comprising
- contacting the liquid medium with a solid extractant having a metal-binding functionality, said metal-binding functionality comprising an unsubstituted or substituted phosphine group, said metal-binding functionality being connected to said solid extractant directly or via a linking moiety which does not include at least one of a hydrocarbylsilyl residue or a polyamine residue;
- and
- separating said drug substance from said liquid medium.
Dependencies are inferred from the claim text.