Method and packaging for pressurized containers
AssigneeAventis Pharma S.A.
InventorFrank C. Barker
Life of this patent
Estimating the term…
Abstract
A method for maintaining the enclosed volume of a sealed package at about ambient pressure, wherein the package contains a pressurized container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof; wherein the method comprises the steps of (1) positioning an effective amount of a HFA adsorbent material, and said pressurized container, within a sealable package; (2) sealing the package so that the pressurized container and adsorbent are in an enclosed volume within the package at a pressure equal to about ambient pressure; and (3) adsorbing any leakage of the HFA propellant into the HFA adsorbent material so as to maintain the enclosed volume at about ambient pressure.
Claims108
A method for maintaining the enclosed volume of a sealed package at about ambient pressure, wherein the package contains presurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof;
- wherein the method comprises the steps of:
- (i) positioning an effective amount of a HFA adsorbent material, and said pressurized container, within a sealable package;
- (ii) sealing the package so that the pressurized container and adsorbent are in an enclosed volume within the package at a pressure equal to about ambient pressure;
- and
- (iii) adsorbing any leakage of the HFA propellant into the HFA adsorbent material so as to maintain the enclosed volume at about ambient pressure.
Use of an HFA adsorbent to maintain the pressure of an enclosed volume within a sealed package at about ambient pressure, wherein the sealed package comprises:
- (i) a pressurized MDI (metered dose inhaler) container comprising a drug, a HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof;
- (ii) an effective amount of an HFA adsorbent material;
- wherein the pressurized MDI container and HFA adsorbent material are within the enclosed volume of the sealed package.
The use according toclaim 33, wherein the package is impermeable to HFA 134a.
A pharmaceutical product comprising:
- (i) a pressurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof;
- (ii) an effective amount of an HFA adsorbent material;
- and
- (iii) a sealed package having an enclosed volume within which the pressurized container and the HFA adsorbent material are situated,
- wherein the sealed package is impermeable to the HFA propellant and the pressure within the enclosed volume of the package is equal to about ambient pressure;
- and
- wherein the HFA adsorbent material is capable of adsorbing the HFA propellant so as to maintain a constant pressure within said enclosed volume, when any leakage of the HFA propellant occurs from the pressurized container.
A pharmaceutical product comprising:
- (i) a pressurized MDI (metered dose inhaler) container comprising a drug, and an HFA (hydrofluoroalkane) propellant selected from the group consisting of HFA 134a and HFA p227, or a mixture thereof;
- (ii) an effective amount of an HFA adsorbent material;
- and
- (iii) a sealed package having an enclosed volume within which the pressurized container and the HFA adsorbent material are situated,
- wherein the pressure within the enclosed volume of the package is equal to about ambient pressure;
- wherein the HFA adsorbent material is capable of adsorbing the HFA propellant so as to maintain a constant pressure within said enclosed volume, when any leakage of the HFA propellant occurs from the pressurized container;
- and
- wherein the package has a permeability to HFA p227 that is less than or equal to about 0.25 cc of HFA p227 per square meter of package per day at about 1 bar pressure and about room temperature, or a permeability to HFA 134a that is less than or equal to about 4.1 cc of HFA 134a per square meter of package per day at about 1 bar pressure and about room temperature.
Dependencies are inferred from the claim text.