Transgenic fish and beta-catenin signaling pathway model
AssigneeUniversity of Washington
InventorsRandall T. Moon, Richard I. Dorsky
Life of this patent
Estimating the term…
Abstract
The present invention is directed a Lef1/β-catenin-dependent reporter and to transgenic fish containing this reporter. The present invention is also directed to the use of the reporter and the transgenic fish as a model for the β-catenin signaling pathway. The model is useful for identifying genes in the β-catenin signaling pathway and for identifying drugs that can modulate the β-catenin signaling pathway. Such drugs are useful for treating or preventing melanoma, colorectal cancer and osteoporosis, among other disease conditions.
Claims29
A reporter nucleic acid comprising a first DNA molecule comprising nucleotides 3005-4336 of SEQ ID NO:1 contiguous to nucleotides 1-243 of SEQ ID NO:1 or a second DNA molecule which has at least 80% identity with said first DNA molecule and which has the same reporter function as said first DNA molecule.
Dependencies are inferred from the claim text.