Prosthetic kidney and its use for treating kidney disease
OwnerAnthony Atala, James J. Yoo +1inventors
InventorsAnthony Atala, James J. Yoo, Samy Ashkar
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Abstract
The invention is directed to a prosthetic kidney, to methods of making a prosthetic kidney and to methods of treating kidney disease with a prosthetic kidney. The prosthetic kidney comprises nephron analogs on the exterior surface and an enclosed porous membrane structure equipped with an effluent channel for collecting and draining urine from the device. The nephron analogs are prepared by implanting a device containing renal tubule analogs on the membrane structures and inducing angiogenesis to form glomeruli-like structures. The renal tubule analogs are prepared by seeding kidney cells on the porous membrane structure and culturing this composite in vitro.
Claims38
A prosthetic kidney comprising at least one artificial renal unit implanted in a host wherein said artificial renal unit comprises a porous membrane structure having an external surface defining an enclosed internal space with at least one effluent channel, said porous membrane structure having attached to the external surface thereof a plurality of nephron analogs, each of said nephron analogs comprising a renal tubule analog and an induced glomeruli structure in at least one region of said renal tubule analog, said renal tubule analog comprising a three-dimensional aggregate of kidney tubule cells having a brush border adapted to be in contact with host tissue to induce formation of the glomeruli structure and a lumen in fluid communication with the internal space of said membrane structure.
An artificial renal unit implanted in a host and comprising a porous membrane structure having an external surface defining an enclosed internal space having at least one effluent channel, said porous membrane structure having attached to the external surface thereof a plurality of nephron analogs, each of said nephron analogs comprising a renal tubule analog and an induced glomeruli structure in at least one region of said renal tubule analog, said renal tubule analog comprising a three-dimensional aggregate of kidney tubule cells having a brush border adapted to be in contact with host tissue to induce formation of the glomeruli structure and a lumen in fluid communication with the internal space of said membrane structure.
(Four times Amended) A nephron analog suitable for implanting in a patient comprising a renal tubule analog attached to a porous membrane structure having an external surface defining an enclosed internal space with at least one effluent channel, wherein said renal tubule analog comprises a three-dimensional aggregate of kidney tubule cells having an exposed brush border configured to contact host tissue to induce formation of a glomeruli structure and a lumen in fluid communication with the internal space of said membrane structure.
Dependencies are inferred from the claim text.