Stent-graft-membrane and method of making the same

An implantable endoprosthesis comprising:

• a first set of filaments each of which extends in a configuration along a center line and having a first common direction of winding;
• a second set of filaments each of which extends in a configuration along a center line and having a second common direction of winding, the first and second filaments forming a stent layer, one or more membrane layers having a first average permeability ranging from about 0 cc/cm2/min. to about 100 cc/cm2/min. at 120 mmHg disposed over or on at least one of an inside, interstices, or outside of the stent or a graft;
• and
• one or more graft layers having a second average permeability ranging from about 50 cc/cm2/min. to about 5000 cc/cm2/min. at 120 mmHg disposed over or on at least one of an inside, interstices, or outside of the stent;
• wherein the first and second set of filaments, one or more membrane layers and one or more graft layers form a self expanding structure having one or more layers, inside surface, outside surface, proximal end, distal end, and a lumen, the inside surface being substantially biocompatible with a fluid flow through the body lumen and the outside surface being substantially biocompatible with a body tissue.

A method of making a stent-graft-membrane comprising the steps:

• forming a first number of elongated members wound helically in a first common direction and crossing a second number of elongated members wound helically in a second common direction, the crossing of the first and second elongated members defining an angle therebetween and forming a generally tubular body having an inside surface, outside surface, ends and a middle portion therebetween, the first and second elongated members braided in a braid pattern and configured to be constranable to a reduced diameter and self-expandable to an increased diameter, the generally tubular body adapted to be disposed at a treatment site in at least one of a body vessel or organ having body tissue;
• forming a passage extending in a longitudinal direction at least partially through the generally tubular body, the passage adapted to at least partially contain a fluid;
• forming one or more outside layers on at least a portion of the outside surface of the tubular body, an outermost layer of the one or more outside layers being biocompatible with the body tissue;
• forming one or more inside layers on at least a portion of the inside surface of the tubular body, an innermost layer of the one or more inside layers being biocompatible with the fluid in the passage;
• wherein at least one of the one or more outside layers or the one or more inside layers are substantially impermeable to a fluid.

A method of making a stent-graft-membrane comprising the steps:

• braiding bioabsorbable filaments to form a tubular braid, the braid having a braid angle;
• disposing the braid on a mandrel;
• annealing the braid for a predetermined time to form an annealed stent;
• removing the stent from the mandrel, the stent having a filament crossing angle;
• forming a graft having a first permeability ranging from about 50 cc/cm2/min. to about 5000 cc/cm2/min. 120 mmHg on at least one of an inside or an outside surface of the stent;
• adhering at least a portion of the graft to the annealed stent;
• and
• forming a membrane having a second average permeability ranging from about 0 cc/cm2/min to about 100 cc/cm2/min. at 120 mmHg on at least a portion of the stenL.

A braided implantable endoprosthesis comprising:

• a first number of elongated members wound helically in a first common direction and crossing a second number of elongated members wound helically in a second common direction, the crossing of the first and second elongated members defining an angle therebetween and forming a generally tubular body having an inside surface, outside surface, ends and a middle portion therebetween, the first and second elongated members braided in a braid pattern and configured to be constrainable to a reduced diameter and self-expandable to an increased diameter, the generally tubular body adapted to be disposed at a treatment site in at least one of a body vessel or organ having body tissue;
• a passage extending in a longitudinal direction at least partially through the generally tubular body, the passage adapted to at least partially contain a fluid;
• one or more outside layers disposed on at least a portion of the outside of the tubular body, at least one of the one or more outside layers being a membrane made of a silicone or a polycarbonate urethane material biocompatible with the body tissue;
• one or more inside layers disposed on at least a portion of the inside of the tubular body, at least one of the one or more inside layers being a graft made of braided PET material biocompatible with the fluid in the passage;
• wherein the braided implantable endoprosthesis is configured such that at least one of the one or more layers are substantially impermeable to a fluid and substantially separate a first body fluid located outside the implantable endoprosthesis from a second body fluid located in the passage.

A method of using a stent-graft-membrane comprising the steps:

• identifying a treatment site;
• determining the tissue, organ or fluid at the treatment site that the inside surface and the outside surface of the stent-graft-membrane are to be associated with;
• determining one or more materials for the inside and outside surfaces of the stent-graft-membrane that are substantially biocompatible with the tissue, organ or fluid at the treatment site;
• providing a stent-graft-membrane, the stent-graft-membrane having a first number of elongated members wound helically in a first common direction and crossing a second number of elongated members wound helically in a second common direction, the crossing of the first and second elongated members defining an angle therebetween and forming a generally tubular body having an inside surface, outside surface, ends and a middle portion therebetween, the first and second elongated members braided in a braid pattern and configured to be constrainable to a reduced diameter and selfexpandable to an increased diameter, the generally tubular body adapted to be disposed at a treatment site in at least one of a body vessel or organ having body tissue;
• a passage extending in a longitudinal direction at least partially through the generally tubular body, the passage adapted to at least partially contain a fluid;
• one or more outside layers disposed over or on at least a portion of the outside of the tubular body, an outermost layer of the one or more outside layers being biocompatible with the body tissue;
• one or more inside layers disposed over or on at least a portion of the inside of the tubular body, an innermost layer of the one or more inside layers being biocompatible with the fluid in the passage;
• wherein at least one of the one or more outside layers or the one or more inside layers are substantially impermeable to fluids;
• inserting the stent-graft-membrane in a delivery device;
• inserting the delivery device into a body and delivering the stent-graft-membrane to the treatment site;
• and
• deploying the stent-graft-membrane into a position at the treatment site.