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AssigneesLucid, Inc., The General Hospital Corporation
InventorsMilind Rajadhyaksha, James M. Zavislan
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A confocal scanning microscope system (10) using cross polarization effects and an enhancement agent (acetic acid) to enhance confocal microscope reflectance images of the nuclei of BCCs (basal cell carcinomas) and SCCs (squamous cell carcinomas) in the confocal reflectance images of excised tumor slices. The confocal scanning microscope system having a laser (11) for generating an illumination beam (12), a polygon mirror (18) for scanning the beam to a tissue sample (22) and for receiving a returned beam from the tissue sample and detector (28) for detecting the returned beam to form an image. The system further includes a half-waveplate (13) having a rotatable stage (14) and a quarter-wave plate (21) having a rotatable stage (20) disposed in the optical path of the illumination beam and at least a linear polarizer (24) having a rotatable stage (25) disposed in the optical path of the returned beam from the tissue sample.
A system for confocal imaging tissue comprising:
A system for providing enhanced images in confocal microscopy which is characterized by utilizing cross polarized light in the illumination of tissue and in the detection of light from which the images are formed, respectively, and wherein an image enhancing agent is used in a bath in which the specimen is immersed while being imaged.
A method for confocal imaging tissue comprising the steps of:
A method for detecting cancerous basal cell and squamous cell in dermal tissue with confocal reflected light imaging, said method comprising the steps of:
Dependencies are inferred from the claim text.