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US 2004/0167360 A1Published application
Process for preparing sertraline hydrochloride polymorphic form II
AssigneeFermion Oy
InventorIlpo Laitinen
Life of this patent
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Abstract
Sertraline hydrochloride, (1Scis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenaminehydrochloride, polymorph II is prepared by extracting or dissolving the sertraline base into ethyl acetate, adding isopropanol as a solvent, adding hydrogen chloride dissolved in ethyl acetate or in gaseous form, and finally isolating and drying sertraline hydrochloride polymorphic form II.
Claims8
A process for preparing sertraline hydrochloride polymorphic form II comprising:
- (a) extracting or dissolving the sertraline base into an organic solvent to obtain a first solution comprising sertraline and said organic solvent;
- (b) adding isopropanol to said first liquid to obtain a second solution comprising sertraline and isopropanol;
- (c) adding gaseous HCl or HCl dissolved in ethyl acetate while controlling the addition rate to obtain a suspension comprising crystals of sertraline hydrochloride polymorphic form II;
- and
- (d) isolating sertraline hydrochloride polymorphic form II.
2 more elements
Dependencies are inferred from the claim text.