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OwnerSonja Suzanne Mackey, Michael e Matison +5inventors
InventorsSonja Suzanne Mackey, Michael e Matison, Haifeng Wu, Paul M Herrinton, Michael Paul Goble, Moses W McMillian, Vikram Gurudath Kalthod
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A process for preparing (S)-(-)-N-[4-[4-[ethyl(6-fluoro-6-methylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide hemifumarate salt, which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyl]phenyl]methanesulfonamide (IIa) with fluoroamine (III) in the presence of triacetoxyborohydride and ethyl acetate to provide [4-[4-[ethyl(6-fluoro-6-metylheptyl)amino]-1-hydroxy]phenyl]methanesulfonamide (I) anll then converting I into the hemifumarate salt Ia. A process for preparing IIa is also claimed as well as intermediates IIa-lId.
A process for preparing (S)-(-)-N-[4-[-4-(ethyl(6-fluoro-6-methyl-heptyl)amino]-1-hydroxybutyl]phenyl] methanesulfonamide (I) which comprises reacting N-[4[(2S)-tetrahydro-5-hydroxy-2-furanyllphenyl]methanesulfonamide (Ila) with flouroamine (III)in the presence of triacetoxy borohydride and ethyl acetate.
A compound having the formula
A fluoroamine compound, N-ethyl-6methyl-6-fluoroheptane amine.
A process for preparing N-ethyl-6-methyl-6-fluoroheptane amine which comprises reacting a solution of 6-bromo-2-fluoro-2-methylheptane with aqueous ethylamine in the presence of a solvent and recovering the N-ethyl-6-methyl-6-fluoroheptane amine from the reaction mixture.
Dependencies are inferred from the claim text.