2-{[n-(2-amino-3-(heteroaryl or aryl)propionyl)-aminoacyl}-amino}-alkylboronic acid derivatives

A compound of the formula I

• 29
• wherein
• R1 is unsubstituted or substituted aryl;
• arylalkylcarbonyl, wherein the aryl moiety is unsubstituted or substituted;
• unsubstituted or substituted heterocyclyl;
• or heterocyclylalkylcarbonyl, wherein the heterocyclyl moiety is unsubstituted or substituted;
• R2 is unsubstituted or substtuted aryl or unsubstituted or substituted heteroaryl;
• R3 is hydrogen, unsubstitued or substituted aryl or alkyl which is unsubstituted or substituted by
• unsubstituted or substituted cycloalkyl,
• unsubstituted or substituted aryl, or
• unsubstituted or substituted heteroaryl comprising at least one nitrogen atom;
• R4 is a moiety of the formula IA,
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• wherein A1 and A2 are hydroxy or substituted hydroxy, or together with the binding boron atom and the two binding oxygen atoms form a ring of the formula IA*,
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• wherein W is alkylene, substituted alkylene, unsubstituted or substituted cycloalkylene, unsubstituted or substituted bicycloalkylene or unsubstituted or substituted tricycloalkylene;
• and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocyclyl, or unsubstituted or substituted cycloalkyl;
• or a salt thereof.