Inhibitors of acyl glucosaminyl inositol amidase and methods of use

A composition having Structure I or Structure II:

• 30
• wherein Z together with the carbon to which it is attached is a monocyclic, bicyclic, tricyclic, tetracyclic or pentacyclic ring, each containing 5-7 members, wherein 0-2 of the members are independently selected from oxygen, sulfur and nitrogen and the remaining members are carbon, wherein each ring contains 0-3 double bonds and is substituted with up to 4 substituents X1, X2, X3 or X4;
• wherein X1, X2, X3 and X4 are independently selected from —F, —Cl, —Br, —I, —OH, —OCH3, and —O(CH2)mQ, wherein m=1-4 and wherein Q is selected from —NH2, —NH(CH2)sCH3, —N[(CH2)sCH3]2, —N+[(CH2)sCH3]3, wherein s=0-3, n=1-6, and r=0-4;
• Y is either selected from N-substituted 2-aminoimidazole and
• 31
• wherein R1, R2, R3, R4, R5, and R6 are independently selected from —H, —CH3, and —(CH2)pCH3, wherein p=0-3, except that R4 is optionally present and —CHR2 and R3 can join to become —C═CR7, forming an imidazole ring, and then R7 is selected from:
• H,
• 32
• wherein X5, X6, and X7 are independently selected from —H,—F, —Cl, —Br, —I, —OH, —OCH3, —NH2, —CONH2 and —O(CH2)mQ, wherein m=1-4 and wherein Q is selected from —NH2, —NH(CH2)sCH3, —N[(CH2)sCH3]2, —N+[(CH2)sCH3]3, wherein s=0-3, n=1-6, and r=0-4;
• or Y is —O—R8, wherein R8 is
• wherein X8 and X9 are independently selected from —F, —Cl, —Br, —I, —OH, —OCH3, and —O(CH2)mQ, wherein m=1-4 and wherein Q is selected from —NH2, —NH
• 33
• wherein X10 is selected from —H or —OH,
• wherein G is selected from —H, —NH2, —N+[(CH2)sCH3]3, —NHC(NH2)═NH, or 2-aminoimidazole, wherein s=0-3, and
• wherein R9 is selected from —H, CH3, (CH2)sCH3 wherein s=0-3, and pharmaceutically suitable salts thereof