Novel compounds
AssigneeSmithKline Beecham Corporation
InventorsNeal Ward, Victor Witold Jacewicz
Life of this patent
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Abstract
Invented is paroxetine hydrochloride anhydrate in Form B and paroxetine hydrochloride anhydrate in Form D. Also invented are pharmacetucal formulations comprising these compounds and methods of using these compounds in therapy.
Claims25
Paroxetine hydrochloride anhydrate substantially free of bound propan-2-ol.
Paroxetine hydrochloride anhydrate substantially free of bound organic solvent.
Paroxetine hydrochloride anhydrate substantially free of bound propan-2-ol with the proviso that it is other than Form Z.
Paroxetine hydrochloride solvates other than the propan-2-ol solvate.
Paroxetine hydrochloride anhydrate substantially free of bound propan-2-ol in substantially pure form.
A process for the preparation of paroxetine hydrochloride anhydrate substantially free of propan-2-ol which comprises crystallizing paroxetine hydrochloride in either,
- i) an organic solvent or mixture of organic solvents which form a solvate with the paroxetine hydrochloride and which are not removable by conventional drying techniques;
- or
- ii) an organic solvent or mixture or organic solvents which do or do not form a solvate with the paroxetine hydrochloride but which are removable by conventional vacuum oven drying;
- thereafter in the case of i) displacing the solvated solvent or solvents using a displacing agent and in the case of ii) by removing the solvent.
A process for the preparation of the paroxetine hydrochloride solvates other than the propan-2-ol solvate which comprises crystallizing paroxetine hydrochloride in an organic solvent or mixture of solvents which form a solvate with the paroxetine hydrochloride and which are not removable by conventional drying techniques.
A process for the preparation of paroxetine hydrochloride anhydrate substantially free of bound organic solvent which comprises displacing the solvated solvent or solvents from a paroxetine hydrochloride solvate using a displacing agent.
A method for treating or preventing any one or more of the Disorders by administering an effective therapeutic or prophylactic amount of the products of the invention to a patient in need thereof.
Dependencies are inferred from the claim text.