Carnitine-magnesium hydroxycitrate
AssigneeLonza Ltd.
InventorsMartin Fuhrmann, Daniel Pianzola
Life of this patent
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Abstract
A method for preparing, from at least one hygroscopic substance, mixtures that can be granulated and that have little hygroscopicity. The corresponding mixtures, especially carnitine-magnesium citrate and carnitine-magnesium hydroxycitrate, are produced.
Claims14
A method for preparing a mixture that can be granulated for dietary supplementation, where the mixture comprises at least one hygroscopic substance, characterized in that
- a) in a first stage the solid hygroscopic substance is mixed with at least one organic acid and at least one metal hydroxide without addition of water or with addition of not more than 15% by weight of water based on the weight of the complete mixture, and in that
- b) in a second stage the water content of a resulting mixture is reduced by drying to below 5% by weight, with the resulting composition preferably remaining pasty.
The method as claimed in any of the preceding claims, characterized in that the resulting composition is a solid or is solidified and is granulated to particles having a size not exceeding 1 mm.
A mixture that can be granulated, comprising salts of carnitine, preferably L-carnitine, at least one alkali metal or alkaline earth metal cation and one organic, physiologically acceptable acid, characterized in that the water uptake of the previously dried mixture after 24 h at a relative humidity of 56% under atmospheric pressure and at 25° C. is not more than 16% by weight, preferably not more than 10% by weight, based on the total weight of the mixture.
A salt compound, characterized in that the salt is carnitine-magnesium hydroxycitrate, and in that the magnesium, the carnitine and the hydroxycitrate are present in a molar ratio 1:1:1.
The salt compound as claimed in claim 14, characterized in that the carnitine is L-carnitine.
The salt compound as claimed in claim 14, characterized in that the salt compound can be prepared in a method as claimed in claim 1.
Dependencies are inferred from the claim text.