Neuroprotective effects of polyphenolic compounds
OwnerGiovanni Scapagnini, Daniel L. Alkon +3inventors
InventorsGiovanni Scapagnini, Daniel L. Alkon, Vittorio Calabrese, Roberto Motterlini, Claudia Colombrita
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Abstract
The invention relates to a class of compounds, and analogs thereof, which are effective in protecting cells of the central and peripheral nervous system from deterioration and cell death arising from degenerative disease, trauma, aging or like condition, disease or disorder. The methods utilize novel anti-apoptotic and neuroprotective effects for a group of natural polyphenols in cells of the central and peripheral nervous system.
Claims11
A method of protecting neuronal cells, central and peripheral nervous system cells, and cells associated therefrom, from cell death in a subject, said method comprising administering an effective amount of a polyphenolic compound, or analog thereof, to said subject, sufficient to protect the neuronal cells, central and peripheral nervous system cells, and those associated thereof, from cell death.
A method of inducing activity of a neuroprotective protein in a subject, said method comprising administering an effective amount of a polyphenolic compound, or analog thereof, to said subject, sufficient to induce activity of a neuroprotective protein.
A method of preventing or treating a disease associated with cell death in neuronal cells, central and peripheral nervous system cells, and cells associated therefrom, in a subject, said method comprising administering an effective amount of a polyphenolic compound, or analog thereof, to said subject, sufficient to prevent or treat a disease associated with cell death in neuronal cells, central and peripheral nervous system cells, and cells associated therefrom.
Dependencies are inferred from the claim text.