Absorption enhancing agents
OwnerRong-Kun Chang, Benjamin Kibalo +4inventors
InventorsRong-Kun Chang, Benjamin Kibalo, Richard A. Couch, Mark J. Ginski, Ali Keshavarz-Shokri, Caren C. Bancroft
Life of this patent
Estimating the term…
Abstract
Disclosed are new compounds that increase the absorption of pharmaceutical agents across mucous membranes. These absorption enhancers allow higher bioavailability of administered drugs. The enhancers advantageously have low or no cytotoxicity.
Claims25
A composition comprising at least one pharmaceutically active agent and an enhancer containing one or more of N,N-dimethylglycine, thioctic acid, sebacic acid, shikimic acid, and salts thereof.
A method for enhancing the absorption of a pharmaceutically active agent across a mucosal membrane in a mammal, comprising administering to the mammal a composition comprising at least one active agent and an enhancer containing one or more of N,N-dimethylglycine, thioctic acid, sebacic acid, shikimic acid, and salts thereof.
A process for testing the potency of an absorption enhancer in vitro, comprising:
- (a) growing a confluent monolayer of Caco-2 cells on a permeable support in a culture chamber with apical and basolateral sides;
- (b) adding a drug selected from sampatrilat or hydrochlorothiazide concurrently or sequentially with a potential enhancer compound to the apical side of the chamber;
- (c) after a predetermined time measuring the amount of drug that passes from the apical side to the basolateral side of the chamber;
- and
- (d) comparing the measurement from step (c) with a measurement obtained from the addition of drug alone to the apical side of the chamber,
- whereby the magnitude of any increase is an indication of the potency of the enhancer.
Dependencies are inferred from the claim text.