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AssigneeTargeGen, Inc.
InventorsWolfgang Wrasidlo, John Doukas, Ivor Royston, Glenn Noronha, John D. Hood, Elena Dneprovskaia, Xianchang Gong, Ute Splittgerber, Ningning Zhao
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Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
A compound of structure (I):
A compound of structure (II):
A compound of structure (III):
A compound of structure (IV):
A compound of structure (V):
A method for treating a disorder associated with compromised vasculostasis, comprising administering to a subject in need thereof an effective amount of a compound, wherein the compound is set forth in Structures I, II, III, IIIa, IV, V, or any combination thereof.
A method for treating a disorder associated with compromised vasculostasis, comprising administering to a subject in need thereof an effective amount of a compound having the structure:
A method for treating a disorder associated with compromised vasculostasis, comprising administering to a subject in need thereof an effective amount of a compound having the structure:
A method for treating a disorder associated with compromised vasculostasis, comprising administering to a subject in need thereof an effective amount of a compound having the structure:
A method for treating a disorder associated with compromised vasculostasis comprising administering to a subject in need thereof an effective amount of a compound having structure (VII):
A pharmaceutical composition comprising a compound as set forth in Structures I, II, III, IIIa, IV, V, or VII, or any combination thereof, in a pharmaceutically acceptable carrier.
An article of manufacture comprising packaging material and a pharmaceutical composition contained within said packaging material, wherein said packaging material comprises a label which indicates that said pharmaceutical composition can be used for treatment of disorders associated with compromised vasculostasis and wherein said pharmaceutical composition comprises a compound set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof.
An article of manufacture comprising packaging material and a pharmaceutical composition contained within said packaging material, wherein said packaging material comprises a label which indicates that said pharmaceutical composition can be used for treatment of disorders associated with vascular permeability leakage or compromised vasculostasis selected from is myocardial infarction, stroke, congestive heart failure, an ischemia or reperfusion injury, cancer, arthritis or other arthropathy, retinopathy or vitreoretinal disease, macular degeneration, autoimmune disease, vascular leakage syndrome, inflammatory disease, edema, transplant rejection, burn, or acute or adult respiratory distress syndrome (ARDS) and wherein said pharmaceutical composition comprises a compound set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof.
A method of treating a disorder associated with compromised vasculostasis, comprising the administration of a therapeutically effective amount of at least one compound set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof, or pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers thereof, to a subject in need of such treatment.
A method of treating a disorder associated with compromised vasculostasis comprising the administration of a therapeutically effective amount of at least one compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof, or pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers thereof, in combination with an anti-inflammatory, chemotherapeutic agent, immunomodulatory agent, therapeutic antibody or a protein kinase inhibitor, to a subject in need of such treatment.
A method of treating a subject having or at risk of having myocardial infarction comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having vascular leakage syndrome (VLS) comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having cancer comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having stroke comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having ARDS comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having burns comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having arthritis comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having edema comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having vascular leakage syndrome (VLS) comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having retinopathy or vitreoretinal disease comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having ischemic or reperfusion related tissue injury or damage, comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having an autoimmune disease, comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having transplant rejection, comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A method of treating a subject having or at risk of having inflammatory disease, comprising administering to the subject a therapeutically effective amount of a compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof thereby treating the subject.
A process for making a pharmaceutical composition comprising combining a combination of a compound set forth in Structures I, II, III, IIIa, IV, V, VI or VII, or any combination thereof or its pharmaceutically acceptable salts, hydrates, solvates, crystal forms salts and individual diastereomers thereof and a pharmaceutically acceptable carrier.
A compound having the structure:
A pharmaceutical composition comprising a compound as set forth in Structure I in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure II in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure III in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure IIIa in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure IV in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure Va or Vb in a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a compound as set forth in Structure VIII in a pharmaceutically acceptable carrier.
A method for inhibiting or reducing vascular leakage in a subject, comprising administering to a subject in need thereof an effective amount of IL-2 in combination with a compound of Structure set forth in Structures I, II, III, IIIa, IV, V, VI or VII or any combination thereof., thereby reducing vascular leakage in the subject
A pharmaceutical composition comprising IL-2 and at least one compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII or any combination thereof, in a concentration effective to reduce vascular leakage associated with IL-2 administration.
A method for treating cancer or a tumor in a subject, comprising administering to a subject in need thereof an effective amount of a therapeutic antibody, chemotherapeutic agent or immunotoxic agents, in combination with a compound set forth in Structures I, II, III, IIIa, IV, V, VI or VII or any combination thereof, thereby treating the cancer or tumor in the subject.
A pharmaceutical composition comprising a therapeutic agent and at least one compound as set forth in Structures I, II, III, IIIa, IV, V, VI or VII or any combination thereof, in a concentration effective to treat cancer in a subject.
Dependencies are inferred from the claim text.