US 2004/0167197 A1 · Compositions, combinations, and methods for treating cardiovascular conditions and other associated conditions

Abstract

This invention is directed generally to a method for treating a pathological condition (particularly a cardiovascular condition (e.g., hypertension or heart failure) or a condition associated with a cardiovascular condition) using a p38-kinase inhibitor (e.g., a p38-kinase-inhibiting substituted pyrazole), and specifically a combination comprising a p38-kinase inhibitor with an angiotensin-converting-enzyme inhibitor (or “ACE inhibitor”) for treating a cardiovascular condition. This invention also is directed generally to combinations comprising a p38-kinase inhibitor, and specifically to combinations comprising a p38-kinase inhibitor with an angiotensin-converting-enzyme inhibitor. This invention is further directed generally to pharmaceutical compositions comprising a p38-kinase inhibitor, and more specifically to compositions comprising the above-described combinations.

Claims31

Dependent claims

A method for treating a pathological condition in a mammal, wherein:

the method comprises administering to the mammal:
a first amount of a compound that comprises a substituted-pyrazole p38-kinase inhibitor, and
a second amount of a compound that comprises an ACE inhibitor;
and
the first and second amounts of the compounds together comprise a therapeutically-effective amount of the compounds.

2 more elements

A method for treating a pathological condition in a mammal, wherein:

the method comprises administering to the mammal:
a first amount of a compound that comprises a p38-kinase inhibitor, and
a second amount of a compound that comprises an ACE inhibitor;
and
the first and second amounts of the compounds together comprise a therapeutically-effective amount of the compounds;
and
the pathological condition comprises a cardiovascular disease, glomerulosclerosis, end-stage renal disease, acute renal failure, diabetic nephropathy, reduced renal blood flow, increased glomerular filtration fraction, decreased glomerular filtration rate, decreased creatine clearance, renal arteriopathy, ischemic renal lesions, vascular damage in the kidney, vascular inflammation in the kidney, malignant nephrosclerosis, thrombotic vascular disease, proliferative arteriopathy, atherosclerosis, decreased vascular compliance, retinopathy, neuropathy, edema, or insulinopathy.

4 more elements

Dependencies are inferred from the claim text.

Compositions, combinations, and methods for treating cardiovascular conditions and other associated conditions

Life of this patent

Compositions, combinations, and methods for treating cardiovascular conditions and other associated conditions

Life of this patent

Abstract

Claims31