Phenethylamino sulfamic acids

A compound according to formula (I):

• 133
• wherein:
• A) R1 is -L1-[C(R6aR6b)]mR7, wherein:
• a) L1 is selected from the group consisting of covalent bond, —O—, —S—, —N—, —CO2—, —CO—, —OCO2—, —SO—, —SO2—, —CSN(R8)—, —CON(R8)O—, —CON(R8)—, —OCON(R8)—;
• wherein R8 is hydrogen or substituted or unsubstituted C1-C5 alkyl;
• b) R6a and R6b are each independently selected from the group consisting of hydrogen, —OR9, —N(R9)2, —CO2R9, —CON(R9)2, —NHCOR9, —NHCO2R9, ═NR9, —R9, and mixtures thereof;
• wherein each R9 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C5 alkyl, and substituted or unsubstituted aryl or alkylenearyl;
• or two R9 units can be taken together to form a substituted or unsubstituted carbocyclic or heterocyclic ring comprising from 3 to 7 atoms;
• c) m is an index selected from 0 to 5;
• d) R7 is selected from the group consisting of nil, hydrogen, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C1-C10 heteroalkyl, substituted or unsubstituted hydrocarbyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl or alkylenearyl, substituted or unsubstituted heteroaryl or alkyleneheteroaryl;
• or
• e) R7 and a R9 can be taken together to form a substituted or unsubstituted carbocyclic or heterocyclic ring comprising from 3 to 7 atoms;
• B) R2 is —(CH2)j-L2-[C(R11aR11b)]gR12, wherein:
• a) j is an index selected from 0 to 5;
• b) L2 is selected from the group consisting of covalent bond, —O—, —S—, —N—, —CO2—, —CO—, —OCO2—, —SO—, —SO2—, —CSN(R10)—, —CON(R10)—, —CON(R10)O—, —OCON(R10)—;
• wherein R10 is hydrogen or substituted or unsubstituted C1-C5 alkyl;
• c) R11a and R11b are each independently selected from the group consisting of hydrogen, —OR13, —N(R13)2, —CO2R13, —CON(R13)2, —NHCOR13, —NHCO2R13, ═NR13, —R13, and mixtures thereof;
• wherein each R13 is independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-C5 alkyl, and substituted or unsubstituted aryl or alkylenearyl;
• or two R13 units can be taken together to form a substituted or unsubstituted carbocyclic or heterocyclic ring comprising from 3 to 7 atoms;
• d) g is an index selected from 0 to 5;
• e) R12 is selected from the group consisting of nil, hydrogen, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted hydrocarbyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl or alkylenearyl, substituted or unsubstituted heteroaryl or alkyleneheteroaryl;
• or
• f) R12 and a R13 can be taken together to form a substituted or unsubstituted carbocyclic or heterocyclic ring comprising from 3 to 7 atoms;
• C) R3 is —(CH2)n-L3-R16, wherein:
• a) n is an index selected from 0 to 5;
• b) L3 is selected from covalent bond, —O—, —S—, —N—, —CO2—, —CO—, —OCO2—, —SO—, —SO2—, —CSNH—, —CONH—, —OCONH—;
• c) R16 is selected from the group consisting of hydrogen, substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C1-C10 heteroalkyl substituted or unsubstituted aryl or alkylenearyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroaryl or alkyleneheteroaryl;
• D) R4a, R4b, R4c and R5 are each independently selected from hydrogen or substituted unit;
• or
• E) R2 and R4a, R4a and R4b, R1 and R2, or R1 and R3 can be taken together to form a substituted or unsubstituted carbocyclic or heterocyclic ring comprising from 3 to 7 atoms.