US 2004/0167171 A1 · Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof

Abstract

A compound represented by the formula: 1 (wherein, R1 and R2 are the same or different and each represents a hydrogen atom, hydrocarbon group or heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3-8 membered iso- or heterocyclic group, R3 represents a cyclic group, a hydroxy group, a mercapto group that may have oxo, or an amino group, R4 represents a hydrogen atom, a hydrocarbon group, a hydroxy group, a mercapto group which may have oxo, or an amino group, or R2 and R4 may link together to form a double bond, X represents a bond or a linear hydrocarbon group, W represents an oxygen atom or a sulfur atom, ring B represents a 5-8 membered nitrogen-containing heterocyclic group, ring C represents a benzene ring, and --- represents a single bond or a double bond), or a salt or a prodrug thereof that has excellent neurodegenerative inhibitory activity and brain penetrability, and is useful as an agent for preventing/treating neurodegenerative diseases.

Claims70

Dependent claims

Compounds represented by formula:

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(wherein, R1 and R2 are the same or different and each represents a hydrogen atom, optionally substituted hydrocarbon group or optionally substituted heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3-8 membered iso- or heterocyclic group which may optionally substituted, R3 represents an optionally substituted cyclic group, X represents a bond or a spacer of 1-3 atoms, and R4 represents a hydrogen atom, an optionally substituted hydrocarbon group, optionally substituted hydroxy group, optionally substituted mercapto group which may have oxo, or an optionally substituted amino group, or R2 and R4 may link together to form a double bond, W represents an oxygen atom or a sulfur atom, ring B represents an optionally substituted 4-8 membered nitrogen-containing heterocyclic group, and ring C represents a benzene ring which may also be optionally substituted in addition to the group represented by ring B but not via a nitrogen atom, and --- represents a single bond or a double bond), or a salt thereof.

Dependencies are inferred from the claim text.

Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof

Life of this patent

Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof

Life of this patent

Abstract

Claims70