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US 2004/0167140 A1Published application
[5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides
AssigneeEmory University
InventorsRaymond F. Schinazi, Dennis C. Liotts
Life of this patent
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Abstract
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
Claims13
A compound of the structure:
- 4 5
- wherein:
- X is O, S, CH2, CHF, or CF2;
- Y is O, S, CH2, CHF, CF2;
- Z is independently O, S or Se;
- R1 is independently H or F;
- R2 is independently H, OH, C1 to C6 alkyl, or C(O)(C1 to C6 alkyl);
- R3 is H, C(O)(C1-C6 alkyl);
- alkyl, or mono-, di- or triphosphate;
- and
- R4 is independently H, F, Cl, Br, I, OH, —O(C1-C6alkyl), —SH, —S(C1-C6alkyl);
- or —C1-C6alkyl.
9 more elements
Dependencies are inferred from the claim text.