Dihydropyrimidines

Compounds of the general formula (I)

• 159
• or their isomeric form (Ia)
• 160
• in which
• R1 represents phenyl, furyl, thienyl, triazolyl, pyridyl, cycloalkyl having 3 to 6 carbon atoms or represents radicals of the formulae
• 161
• where the abovementioned ring systems are optionally mono- or polysubstituted by identical or different substituents selected from the group consisting of halogen, trifluoromethyl, nitro, cyano, trifluoromethoxy, carboxyl, hydroxyl, (C1-C6)-alkoxy, (C1-C6)-alkoxycarbonyl and (C1-C6)-alkyl, which for its part may be substituted by aryl having 6 to 10 carbon atoms or halogen,
• and/or the ring systems mentioned are optionally substituted by groups of the formulae —S—R6, NR7R8, CO—NR9R10, SO2—CF3 and -A-CH2—R11,
• in which
• R6 represents phenyl which is optionally substituted by halogen,
• R7, R1, R9 and R10 are identical or different, and each represents hydrogen, phenyl, hydroxyl-substituted phenyl, hydroxyl, (C1-C6)-acyl or (C1-C6)-alkyl, which for its part may be substituted by hydroxyl, (C1-C6)-alkoxycarbonyl, phenyl or hydroxyl-substituted phenyl,
• A represents a radical O, S, SO or SO2,
• R11 represents phenyl which is optionally mono- to polysubstituted by identical or different substituents selected from the group consisting of halogen, nitro, trifluoromethyl, (C1-C6)-alkyl and (C1-C6)-alkoxy,
• R2 represents a radical of the formula —XR12 or —NR13R14,
• in which
• X represents a bond or oxygen,
• R12 represents hydrogen, straight-chain or branched (C1-C6)-alkoxycarbonyl or a straight-chain, branched or cyclic saturated or unsaturated (C1-C6)-hydrocarbon radical which optionally contains one or two identical or different hetero chain members from the group consisting of O, CO, NH, —NH—(C1-C4)-alkyl, —N-((C1-C4)-alkyl)2, S and SO2 and which is optionally substituted by halogen, nitro, cyano, hydroxyl, aryl having 6 to 10 carbon atoms or aralkyl having 6 to 10 carbon atoms, heteroaryl or a group of the formula —NR15R16,
• in which
• R15 and R16 are identical or different, and each represents hydrogen, benzyl or (C1-C6)-alkyl,
• R13 and R14 are identical or different, and each represents hydrogen, (C1-C6)-alkyl or cycloalkyl having 3 to 6 carbon atoms,
• R3 represents hydrogen, amino or
• represents a radical of the formula
• 162
• or
• represents formyl, cyano, trifluoromethyl or pyridyl, or
• represents a straight-chain, branched or cyclic saturated or unsaturated hydrocarbon radical having up to 8 carbon atoms which is optionally mono- or polysubstituted by identical or different substituents from the group consisting of aryloxy having 6 to 10 carbon atoms, azido, cyano, hydroxyl, carboxyl, (C1-C6)-alkoxycarbonyl, a 5- to 7-membered heterocyclic ring, (C1-C6)-alkylthio and (C1-C6)-alkoxy, which for its part may be substituted by azido or amino,
• and/or is substituted by triazolyl, which for its part may be substituted up to 3 times by (C1-C6)-alkoxycarbonyl,
• and/or may be substituted by groups of the formulae —OSO2—CH3 or (CO)a—NR R18,
• in which
• a represents a number 0 or 1,
• R17 and R18 are identical or different, and each represents hydrogen or aryl, aralkyl having 6 to 10 carbon atoms,
• or represents (C1-C6)-alkyl which is optionally substituted by (C1-C6)-alkoxycarbonyl, hydroxyl, phenyl or benzyl, where phenyl or benzyl are optionally mono- or polysubstituted by identical or different substituents from the group consisting of hydroxyl, carboxyl, (C1-C6)-alkyl and (C1-C6)-alkoxy,
• or (C1-C6)-alkyl is optionally substituted by groups of the formulae NH—CO—CH3 or NH—CO—CF3, or
• R17 and R18 together with the nitrogen atom form a morpholine, piperidinyl or pyrrolidinyl ring, or
• R3 represents phenyl which is optionally substituted by methoxy, or
• R2 and R3 together form a radical of the formula
• 163
• R4 represents hydrogen, (C1-C4)-alkyl, (C2-C4)-alkenyl, benzoyl or represents acyl having 2 to 6 carbon atoms,
• R5 represents pyridyl which is substituted up to 3 times by identical or different substituents from the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, (C1-C6)-alkoxy, (C1-C6)-alkyl, (C1-C6)-alkylthio, carbalkoxy, (C1-C6)-acyloxy, amino, nitro, mono- and (C1-C6)-dialkylamino,
• and salts thereof.