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OwnerChristian Bruns, Elisabeth Buchdunger +4inventors
InventorsChristian Bruns, Elisabeth Buchdunger, Terence O'Reilly, Sandra Leta Silberman, Markus Wartmann, Gisbert Weckbecker
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A method of treating a warm-blooded animal, especially a human, having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piper-azino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents, especially as defined herein, and agents effective in treating acute or chronic transplant rejection; a combination comprising (a) and (b) as defined above and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease.
Method of treating a warm-blooded animal having a proliferative disease or acute or chronic transplant rejection comprising administering to the animal a combination which comprises (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from anti-neoplastic agents selected from the group consisting of aromatase inhibitors, antiestrogens, topomerase I Inhibitors, topomerase II inhibitors selected from the group consisting of epirubicin, idarubicin, nemorubicin, the anthraquinones mitoxantrone and losoxantrone and teniposide, microtubule active agents selected from the group O consisting of paclitaxel, vinblastine, vinorelbine and discodermolide, alkylating agents selected from the group consisting of ifosfamide andmelphalan, antineoplastic antimetabolites selected from the group consisting of 5-fluorouracil, capecitabine, gemcitabine and edatrexate, platin compounds and compounds decreasing the protein kinase activity and further anti-angiogenic compounds selected from the group consisting of compounds decreasing the activity of the vascular endothelial growth factor (VEGF), of the platelet derived growth factor (PDGF) and protein kinase and of protein kinase C and anti-angiogenic compounds having another mechanism for their activity, gonadrolin agonists, anti-androgens and tratuzumab and agents effective, in treating acute or chronic transplant rejection, in a quantity which is jointly therapeutically effective against a proliferative disease or acute or chronic transplant rejection and in which the compounds mentioned under (a) and (b) can also be present in the form of their pharmaceutically acceptable salts or any hydrate thereof.
Method according to claim wherein the compound (a) is used in the form of its monomethanesulfonate salt.
A combination which comprises (a) N-{5-[4(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents selected from the group consisting of aromatase inhibitors, antiestrogens, topomerase I inhibitors, topomerase II inhibitors selected from the group consisting of epirubicin, idarubicin, nemorubicin, the anthraquinones mitoxonatrone and losoxantrone and teniposide, microtubule active agents selected from the groupo consisting of paclitaxel, vinblastine, vinorelbine arid discodermolide, alkylating agents selected from the group consisting of ifosfamide andmelphalan, antineoplastic antimetabolites selected from the group consisting of 5-fluorouracil, capecitabine, gemcitabine and edatrexate, platin compounds and compounds decreasing the protein kinase activity and further anti-angiogenic compounds selected from the group consisting of compounds decreasing the activity of the vascular endothelial growth factor (VEGF), of the platelet derived growth factor (PDGF) and protein kinase and of protein kinase C and anti-angiogenic compounds having another mechanism for their activity, gonadrolin agonists, anti-androgens and tratuzumab and agents effective in treating acute or chronic transplant rejection, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof, and optionally at least one pharmaceutically acceptable carrier;
A commercial package comprising (a) N-{5-[4-(4-methyl-piperazino-methyl)-benzoyl-amido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and (b) a chemotherapeutic agent selected from antineoplastic agents selected from the group consisting of aromatase inhibitors, antiestrogens, topomerase I inhibitors, topomerase II inhibitors selected from the group consisting of epirubicin, idarubicin, nemorubicin, the anthraquinones mitoxonatrone and losoxantrone and teniposide, microtubule active agents selected from the groupo consisting of paclitaxel, vinblastine, vinorelbine and discodermolide, alkylating agents selected from the group consisting of ifosfamide andmelphalan, antineoplastic antimetabolites selected from the group consisting of 5-fluorouracil, capecitabine, gemcitabine and edatrexate, plain compounds and compounds decreasing the protein kinase activity and further anti-angiogenic compounds selected from the group consisting of compounds decreasing the activity of the vascular endothelial growth factor (VEGF), of the platelet derived growth factor (PDGF) and protein kinase and of protein kinase C and anti-angiogenic compounds having another mechanism for their activity, gonadrolin agonists, anti-androgens and tratuzumab and agents effective in treating acute or chronic transplant rejection, wherein the active ingredients are present in each case in free form or in the form of a pharmaceutically acceptable salt or any hydrate thereof, together with instructions for simultaneous, separate or sequential use thereof in the delay of progression or treatment of a proliferative disease or acute or chronic transplant rejection.
Dependencies are inferred from the claim text.