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US 2004/0167130 A1Published application
Process for making mycophenolate mofetil by transesterification
AssigneeChunghwa Chemical Synthesis & Biotech Co. Ltd.
InventorsKwang-Chung Lee, Shu-Chuan Lin, Ray-Hwa Chiu
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Abstract
A process for making mycophenolate mofetil comprising: conducting a catalytic transesterification by reacting a low-carbon alkyl ester of mycophenolic acid with 2-morpholinoethanol [also named as 4-(2-hydroxyethyl) morpholine] to obtain a crude product of mycophenolate mofetil, which is then isolated and purified.
Claims5
A process for making mycophenolate mofetil comprising:
- transesterification by reacting alkyl mycophenolate with 2-morpholinoethanol in the presence of catalyst to obtain the mycophenolate mofetil.
A process for making mycophenolate mofetil comprising the steps of:
- A. conducting a transesterification by reacting an alkyl mycophenolate with 2-morpholinoethanol in the presence of an organic solvent and a catalyst selected from the group consisting of alkaline metal salt, alkaline earth metal salt, tin oxide and stannous oxide to produce crude mycophenolate mofetil;
- B. adding an acid aqueous solution into said crude mycophenolate mofetil to form an acid salt of mycophenolate mofetil to be soluble in the acid aqueous solution to be separated from the unreacted reactants insoluble in the acid aqueous solution;
- C. basifying the acid aqueous solution to be a base equeous solution by adding a base therein;
- and
- D. extracting the mycophenolate mefetil from the base aqueous solution by an extracting organic solvent, and purifying the mycophenolate mofetil.
2 more elements
Dependencies are inferred from the claim text.