Zinc ionophores as therapeutic agents
OwnerHenry Flissinventor
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Abstract
The present invention provides methods and compositions comprising one or more zinc ionophores for protecting tissue from the harmful effects of apoptosis in patients in need thereof. Concentrations of zinc-pyrithione and diethyldithiocarbamate in the picomolar to nanomolar range have a strong protective effect against apoptosis.
Claims45
A method of treating apoptosis comprising administering to a subject in need thereof a pharmaceutically effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
A method of treating the harmful effects of injurious agents selected from the group consisting of oxidants, TNFα, neurotoxins, and radiation comprising administering to a subject in need of such protection an effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a zinc ionophore and a pharmaceutically acceptable carrier.
A method of treating ischemia comprising administering to a subject in need thereof an effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
A method of treating seizures comprising administering to a subject in need of thereof an effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
A method of treating conditions caused by apoptosis comprising administering to a subject in need thereof an effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
An anti-epileptic composition comprising a zinc ionophore and a pharmaceutically acceptable carrier.
A method of preventing seizures comprising administering to a subject in need thereof an effective amount of a zinc ionophore and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.