Use of estrogen receptor alpha modulators for the treatment of multiple sclerosis
AssigneeWyeth
InventorsM. Merle Elloso, Robert Mitchell, Douglas C. Harnish, Steven J. Adelman
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Abstract
The present invention provides methods of treating an autoimmune pathology in a mammal, comprising administering an agent with estrogen receptor α agonist activity in particular a selective estrogen receptor modulator, to the mammal in an amount sufficient to decrease production of TH-1 and/or TH-2 cytokines. Also provided is a method of selecting compounds useful for the treatment of multiple sclerosis, comprising selecting a compound which has estrogen receptor α agonist activity.
Claims25
A method of treating an autoimmune pathology in a mammal, comprising administering at least one agent having estrogen receptor α agonist activity to the mammal in an amount sufficient to decrease production of TH-1 and/or TH-2 cytokines.
A method of selecting compounds useful for the treatment of multiple sclerosis, comprising selecting a compound which has estrogen receptor α agonist activity.
Dependencies are inferred from the claim text.