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US 2004/0167090 A1Published application
Covalent modification of RNA for in vitro and in vivo delivery
OwnerSean D. Monahan, Vladimir G. Budker +3inventors
InventorsSean D. Monahan, Vladimir G. Budker, Lisa Nader, Vladimir Subbotin, Jon A. Wolff
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Abstract
The post-synthetic modification of RNA for the delivery of the RNA to a mammalian cell is described. The modifications enhance resistant of the RNA to nuclease digestion and delivery of the RNA to the cell whether the RNA is delivered alone or in combination with a transfection agent. Activity of the RNA in the cell is maintained.
Claims20
A composition for delivering an RNA to a mammalian cell comprising:
- a post-synthetically modified RNA.
A process for delivering an RNA to a mammalian cell comprising:
- post-synthetically modifying the RNA through silylation, acylation or alkylation to form a modified RNA, and contacting the cell with the modified RNA.
Dependencies are inferred from the claim text.