Glucopyranoside benzothiophenes
OwnerJeffrey A. Dodge, Charles A. Frolik +3inventors
InventorsJeffrey A. Dodge, Charles A. Frolik, Terry D. Lindstrom, Charles W. Lugar III, Gilbert S. Staten
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Abstract
A compound of the formula 1 or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation thereof.
Claims8
A compound of the formula
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- or a pharmaceutically acceptable salt or solvate thereof.
A method of inhibiting bone loss comprising administering a compound of formula (I) to a human in need thereof.
A method of lowering serum lipid level, comprising administering a compound of formula (I) to a human in need thereof.
A formulation comprising a compound of formula (I) and one or more suitable excipients, diluents, or carriers.
A process for preparing a compound of the formula
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- wherein R1 is hydrogen or a group of the formula
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- and R2 is hydrogen or a group of the formula
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- or a salt or solvate thereof, with the proviso that one of R1 or R2 is hydrogen, comprising reacting a compound of the formula
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- wherein R1′ is a hydroxy protecting group or a group of the formula
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- or R2′ is a hydroxy protecting group or a group of the formula
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- or a salt or solvate thereof, with the proviso that one of R1′ and R2′ is a hydroxy protecting group, with a suitable base,and a hydroxy-protecting group cleaving agent, in a suitable polar organic solvent, for a time and at a temperature sufficient to provide a compound of formula (II).
Dependencies are inferred from the claim text.