Novel ascorbic acid compounds, methods of synthesis and application use thereof
AssigneeMatthias Rath
InventorsWaheed M. Roomi, Shrirang Netke, Vadim Ivanov, Aleksandra Niedzwiecki, Matthias Rath
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Abstract
A composition of L-ascorbic acid derivatives is described comprising L-ascorbic acid and lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties. The composition so described is used to prevent the degradation of extracellular matrix, stabilize connective tissue, is used to as an antioxident, and is used for treating damage to skin comprising applying the topical composition to the skin.
Claims50
A composition of L-ascorbic acid derivatives, comprising:
- a. L-ascorbic acid and
- b. lysine or lysine moieties, wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties.
A composition of L-ascorbic acid derivatives, comprising:
- a. L-ascorbic acid and
- b. proline or proline moieties wherein the proline or proline moieties are covalently bound to L-ascorbic acid.
A method of preparing L-ascorbic acid derivatives, comprising the steps of:
- 1) treating 6-deoxybromoascorbate with lysine or lysine moieties wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties;
- and
- 2) isolating the L-ascorbic acid derivatives;
- wherein the 6-deoxybromoascorbate is covalently bound to one lysine.
A method of preparing L-ascorbic acid derivatives, comprising the steps of:
- 1) treating 6-deoxybromoascorbate with proline or proline moieties wherein L-ascorbic acid is covalently bound to the proline or proline moieties;
- and
- 2) isolating said L-ascorbic acid derivatives.
A method of preparing L-ascorbic acid derivatives, comprising the steps of:
- 1) treating 6-deoxybromoascorbate with lysine or lysine moieties and proline or proline moieties wherein L-ascorbic acid is covalently bound to the lysine or lysine moieties and proline or proline moieties;
- and
- 2) isolating said L-ascorbic acid derivatives.
A method of producing L-ascorbic acid derivatives, comprising the steps of:
- 1) treating 6-deoxybromoascorbate with lysine/lysine moieties and proline/proline moieties wherein L-ascorbic acid is covalently bound to the lysine/lysine moieties and proline/proline moieties;
- and
- 2) isolating said L-ascorbic acid derivatives;
- wherein the 6-deoxyaminoascorbate is covalently bound to the carboxyl group of polyproline at C-6 position of the L-ascorbic acid.
A pharmaceutical composition comprising an L-ascorbic acid derivative as an effective ingredient, together with a pharmaceutical acceptable carrier, wherein the L-ascorbic acid derivative is selected from the group consisting of ascorbyl-6-lysine, ascorbyl-2-lysine, ascorbyl-6-polylysine, ascorbyl-2,6-dilysine, ascorbyl-6-polylysine-2-lysine, ascorbyl-6-lysine-2-polylysine, ascorbyl-2,6-polylysine, ascorbyl-6-proline, ascorbyl-2-proline, ascorbyl-6-polyproline, ascorbyl-2-polyproline, ascorbyl-2,6-diproline, ascorbyl-2-proline-6-polyproline, ascorbyl-2-polyproline-6-proline, ascorbyl-2,6-diproline, 6deoxyascrobyllysine, 6-deoxyascorbylproline, 6-deoxyascorbylpolylysine, 6deoxyascorbylpolyproline, 6-deoxyascorbyllysine-2-proline, 6-deoxyascorbylproline-2-lysine, 6-deoxyascorbylpolylysine-2-proline, 6-deoxyascorbylpolyproline-2-lysine, 6-deoxyascorbyllysine-2-polyproline, 6-deoxyascorbylproline-2-polylysine, 6-deoxyascorbate proline-2-lysine-proline, 6-deoxyascorbate-2-proline-lysine, 6-deoxyascorbyllysine, 6-deoxyascorbate-lysine-proline, 6-deoxyascorbyl-lysine-2-proline, 6-deoxyascorbyl-polylysine-2-proline, 6-deoxyascorbyl-lysine-2-polyproline, 6-deoxyascorbyl-lysine-2lysine-proline, 6-deoxyamino ascorbyl-polylysine, 6-deoxyamino ascorbyl-lysine-proline, 6-deoxyamino ascorbylproline, 6-deoxyamino ascorblypolyproline.
Dependencies are inferred from the claim text.