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US 2004/0167076 A1Published application
Modulation of aqueous humor outflow by targeting vascular-endothelial-cadherin in schlemm's canal cells
OwnerW. Daniel Stamer, Ronald L. Heimarkinventors
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Abstract
The present invention provides methods of inhibiting cadherins between Schlemm's canal cells, to a patient suffering from glaucoma as well as screening for substances that inhibit cadherins between the Schlemm's canal cells.
Claims22
A method of treating glaucoma comprising, administering one or more cadherin inhibitors to a mammalian patient in need thereof, in an amount sufficient to inhibit a cadherin between Schlemm's canal cells to treat glaucoma in the mammalian patient.
A method for screening for a substance that inhibits a cadherin between Schlemm's canal cells, comprising contacting the Schlemm's canal cells with the substance;
- and detecting the inhibition of the cadherin between the Schlemm's canal cells, which is indicative that the substance inhibits a cadherin between Schlemm's canal cells.
Dependencies are inferred from the claim text.