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US 2004/0166572 A1Published application
Reagents for protection of peptide/proteins carbamylation in urea solutions utilizing non-ethylene-diamine like compounds
AssigneeN.V. Organon
InventorsMin Wan, Phillip Ropp
Life of this patent
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Abstract
The present invention generally relates to non-ethylene diamine like compounds that prevent and/or delay carbamylation of peptides.
Claims12
A process for inhibiting and/or delaying carbamylation of a peptide/protein in a urea and/or cyanate containing solution during processing of said peptide/protein comprising the step of adding a carbamylation inhibiting compound to the process wherein said compound is not an ethylene diamine like compound.
The process of claim 7 wherein the ribonuclease is RNase A.
The process of wherein the carbamylation percent protection is about 100% after three weeks.
Dependencies are inferred from the claim text.