Vectors for gene therapy
OwnerJane F. Apperley, Marina I. Garininventors
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Abstract
A polynucleotide encoding a thymidine kinase wherein the thymidine kinase coding region does not contain a functional splice acceptor and/or splice donor site. An expression vector comprising said polynucleotide. The polynucleotides and expression vectors are useful in gene therapy. The polynucleotides and vectors are useful in destroying cells when used in conjunction with a substantially non-toxic agent, such as ganciclovir, which is converted by thymidine kinase to a toxic agent.
Claims30
A polynucleotide encoding a thymidine kinase wherein the thymidine kinase coding region does not contain a functional splice acceptor and/or splice donor site.
A polynucleotide according to any one of the preceding claims wherein the thymidine kinase coding region encodes wild type thymidine kinase.
A polynucleotide according to any one of the preceding claims further comprising a promoter in operable linkage to allow for expression of the coding region.
An expression vector comprising a polynucleotide as defined in any one of the preceding claims.
Any novel gene therapy vector or system as herein disclosed.
Dependencies are inferred from the claim text.