Cytoplasmic antigens for detection of candida
AssigneeRockeby Biomed Ltd.
InventorsJohn Warmington, Denis Ballantyne
Life of this patent
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Abstract
The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or suspected to be suffering from a Candida infection.
Claims16
A method of diagnosing Candida infection, comprising the steps of:
- a). obtaining a biological sample from a subject at risk of, or suspected to be suffering from, Candida infection, and
- b). measuring the levels of antibody to Candida cytoplasmic antigen present in the biological sample.
A method for assessing the prognosis of Candida infection, comprising the steps of measuring the levels of antibody to Candida cytoplasmic antigen in a biological sample.
A method of detecting the presence or absence of a Candida antibody comprising the steps of:
- a). exposing a biological sample, which may include a Candida antibody, to an isolated cytoplasmic Candida antigen;
- and
- b). detecting the reaction between antibody and antigen.
A method of diagnosing Candida infection, comprising the steps of:
- a). obtaining a biological sample from a subject at risk of, or suspected to be suffering from, Candida infection, and
- b). measuring the levels of antibody present in the biological sample to Candida cytoplasmic antigen in combination with measuring the levels of antibody to either cell wall antigen or immunodominant antigen (enolase) or both.
A kit when used for detecting the presence or absence of a Candida antibody in a biological sample, comprising:
- a). a biological sample collection device;
- b). a cytoplasmic Candida antigen;
- and
- c). means for detecting reaction between the antibody and antigen in the sample.
A method of preparing a cytoplasmic antigen comprising the step of removing lipoproteins by chloroform extraction.
Dependencies are inferred from the claim text.