Compositions and methods for the diagnosis and treatment of sepsis
AssigneeThe Regents of the University of Michigan
InventorsRenfeng Guo, Niels C. Riedemann, Peter A. Ward, Markus Huber-Lang, J. Vidya Sarma
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Abstract
The present invention relates to methods and compositions for the diagnosis and treatment of sepsis. The present invention also provides methods of providing a prognosis to a patient with sepsis. In particular, the present invention relates to compositions and methods for the detection of C5aR expression and the correlation of C5aR expression level with prognosis in sepsis.
Claims30
A method of determining a prognosis, comprising:
- a) providing a blood sample from a subject, wherein said blood sample comprises neutrophils, and wherein said subject is diagnosed with sepsis;
- and
- b) detecting the level of expression of C5aR on said neutrophils.
A method of screening compounds, comprising
- a) providing
- i) a neutrophil, wherein said neutrophil expresses C5aR;
- and
- ii) one or more test compounds;
- and
- b) contacting said neutrophil with said test compound;
- and
- c) detecting the level at which said neutrophil expresses said C5aR.
A kit for providing a prognosis to a subject diagnosed with sepsis, comprising
- a) a reagent for determining the level of C5aR expression on a neutrophil;
- and
- b) instructions for using said reagent for providing a prognosis to said subject.
A method of treating sepsis, comprising
- a) providing a reagent capable of blocking a C5a receptor;
- and
- b) administering said reagent to a subject suffering from sepsis.
Dependencies are inferred from the claim text.