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US 2004/0166517 A1Published application
Cancer associated protein
OwnerJonathan Alexander Terrettinventor
Life of this patent
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Abstract
The present invention relates to a sulphate transporter protein (DTD) and its involvement in cancer, particularly breast cancer, compositions comprising the protein and antibodies which are immunospecific for the protein. The use of the protein in the diagnosis, screening, treatment and prophylaxis of breast cancer is also provided.
Claims18
A method for screening and/or diagnosing cancer in a subject, which method comprises a step of detecting and/or quantifying in a biological sample of said subject, a material selected from the group consisting of:
- (i) a DTD polypeptide, said DTD polypeptide comprising:
- a) an amino acid sequence of SEQ ID NO:
- 1;
- b) an amino acid sequence of SEQ ID NO:
- 1 having one or more amino acid substitutions, deletions or insertions;
- c) a fragment of an amino acid sequence of a) or b), said fragment comprising at least ten amino acids;
- and
- (ii) a nucleic acid molecule, said nucleic acid molecule comprising:
- d) a nucleic acid sequence of SEQ ID NO:
- 2 or an RNA transcribed therefrom;
- e) a nucleic acid sequence encoding an amino acid sequence comprising a) SEQ ID NO:
- 1, b) or c);
- f) a nucleic acid sequence complementary to a nucleic acid sequence of d) or e);
- g) a nucleic acid sequence encoding a polypeptide, wherein said polypeptide is identical to an amino acid sequence encoded by a nucleic acid sequence of d) or e);
- or
- h) a nucleic acid sequence having substantial identity to a nucleic acid sequence of d), e), f) or g).
13 more elements
Dependencies are inferred from the claim text.