Microarray-based diagnosis of pediatric hearing impairment-construction of a deafness gene chip
OwnerJohn H. Greinwald JR., Richard J. Wenstrup +1inventors
InventorsJohn H. Greinwald JR., Richard J. Wenstrup, Bruce J. Aronow
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Abstract
The present invention is related to diagnostic arrays comprising primers for various regions of candidate genes involved in hearing loss, specifically pediatric hearing loss. The invention further is directed to methods for diagnosing a cause or risk factor for hearing loss. In some embodiments, these methods include obtaining a sample from a patient; screening the sample for the presence or absence of alleles of at least 5 loci associated with a risk for hearing loss to obtain a result of the screening; and making a diagnosis based upon the result.
Claims24
A method for diagnosing a cause or risk factor for hearing loss, comprising:
- obtaining a sample from a patient;
- screening the sample for the presence or absence of alleles of at least 5 loci associated with a risk for hearing loss to obtain a result of the screening;
- making a diagnosis based upon the result.
A diagnostic hearing loss microarray comprising at least 5 sequences that are indicative of presence or absence of an allele associated with a risk for hearing loss.
Dependencies are inferred from the claim text.