Novel translational activity-promoting higher-order structure
AssigneeNational Institute of Agrobiological Sciences
InventorsNobuhiko Nakashima, Yasushi Kanamori
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Abstract
The present invention was conceived from the findings; that a specific higher-order structure can be formed in CrP-like viruses; that linkage of a gene reading frame downstream in the higher-order structure permits initiating the translation of a protein from various amino acids; and that a change in the combination of base pairs involved in the formation of the higher-order structure immediately upstream in the translation initiation site permits initiating the synthesis of any protein from any codon.
Claims11
An RNA higher-order structure having a function for promoting a translation activity which is made up of a base sequence selected from the group consisting of;
- 1) a base sequence expressed by sequences designated in Sequence Nos. 1 to 7 of the sequence list;
- 2) a base sequence containing the base sequence of 1);
- 3) a base sequence that has in least about 50% of homology in sequence to the base sequence of 1) and that has a function for promoting a translation activity;
- 4) a complementary strand of the base sequences of 1) to 3);
- 5) a base sequence hybridizing with the base sequences of 1) to 4) under stringent conditions;
- and
- 6) a base sequence that has been mutated by deletion, substitution, addition, or insertion of one or more base(s) in the base sequences of 1) to 5) and that has a function for promoting a translation activity.
Dependencies are inferred from the claim text.